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  • دانلود مقاله بررسي تأثير مكمل ياري كلسيم بر پروفايل ليپيدي زنان مبتلا به اضافه وزن يا چاقي1

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    قسمتی از متن :
    امروزه، اضافه وزن و چاقي (به ترتيب نمايه توده بدني يا BMI بين 9/29-25 و 30 كيلوگرم بر متر مربع (1 )) به شكل اپيدمي جهاني در آمده است، تا جايي كه سازمان جهاني بهداشت (WHO ) واژه "globesity"را براي آن در نظر گرفته است. اپيدمي چاقي به جوامع صنعتي و پيشرفته محدود نبوده و تخمين زده مي‏شود كه بيش از 115ميليون نفر در كشورهاي در حال توسعه از مشكلات مربوط به چاقي رنج مي‏برند (2). براي نمونه، در يك مطالعه ملي در زنان 60-40 ساله شهري ايران، در 9/38% اضافه وزن و 9/27% چاقي مشاهده شده است (3).
    علاوه بر چاقي، هيپرليپيدمي نيز از مهمترين عوامل خطرساز بيماري‏هاي قلبي – عروقي است (4) که خود اولين علت مرگ و مير شناخته شده است(5). نكته قابل توجه اينكه چاقي، خود يك عامل خطرساز براي هيپرليپيدمي بوده و هر ساله در كشورهاي مختلف هزينه‏هاي هنگفتي صرف كنترل و درمان چاقي و بيماري‏هاي مرتبط با آن از جمله هيپرليپيدمي مي‏شود كه اهميت پيشگيري و درمان ارزان‏تر آن را بيشتر مي‏كند. براي مثال هزينه‏هاي ملي مربوط به تشخيص، درمان و مديريت اضافه وزن، چاقي و بيماري‏هاي مربوطه در ايالات متحده 5/78 ميليارد دلار در سال 1998تخمين زده شده است (6).
    بيش از 20سال پيش، از آناليز داده‏هاي اولين بررسي ملي سلامت و تغذيه(NHANES-I) آمريكا (7و8) ارتباط معكوس بين دريافت كلسيم و وزن گزارش شد. مطالعه NHANES-III(9) و مطالعات مقطعي بعدي نشان دادند كه افزايش دريافت كلسيم با BMIو وزن پايين‏تر (10و11)، چربي تام بدني كمتر (15-12، 7)، چربي شكمي كمتر (16، 13،12، 7)، محيط كمر كمتر ( 17و 7 ) و حتي برگشت وزن كمتر پس از رژيم‏هاي كاهش وزن (18و12) همراه بوده و اين تاثيرات در سنين كمتر از 18 سال نيز مشاهده مي‏شود (23-19).

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